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It is not prescribed for intolerance to sertraline, it is not used in pediatrics, for treatment of children under six years of age. Contraindicated in the use of patients undergoing therapy with drugs that inhibit monoamine oxidase. The drug should be used with caution for organic lesions of the brain, with mental retardation, epileptic seizures, insufficiency of hepatic and renal function, and anorexia.